Table of Contents
Preface: Tribute to J Waldenström
Part I: Tumor Cells and microenvironment
1. Waldenström Macroglobulinaemia: Pathological Features and Diagnostic Assessment
2. Waldenström’s Macroglobulinemia Immunophenotype
3. Predispositions and Origins of Waldenstrom Macroglobulinemia: Implications from Genetic Analysis
4. Cytogenetics in Waldenström Macroglobulinemia (WM)
5. Genetic and Signaling Abnormalities in Waldenström’s Macroglobulinemia
6. Molecular Pathways in Growth and Survival: Epigenomics
7. The Bone Marrow Microenvironment and Tumor Cells Interactions in Waldenström’s Macroglobulinemia
8. Waldenström’s Macroglobulinaemia: Immunosurveillance and the Immune Micro-environment
Part II: Epidemiology and Genetic Predisposition
9. Epidemiology of Waldenström Macroglobulinemia
10. Genetic Predisposition to Waldenström Macroglobulinemia
11. Immunoglobulin Type M Monoclonal Gammopathy of Undetermined Significance (IgM-MGUS)
Part III Clinical Features
12. Hyperviscosity Syndrome, Cold Agglutinin Hemolytic Anemia, and Cryoglobulinemia
13. Neuropathy in Waldenström’s Macroglobulinaemia
14. IgM Amyloidosis
15. The Bing-Neel Syndrome
16. Unusual Manifestations of IgM Monoclonal Gammopathies
Part IV: Laboratory Investigations
17. Laboratory Investigations and Findings: Hematological Abnormalities, Biochemical Investigations, Free Light and Heavy Chains
Part V: Response
18. Response Assessment in Waldenström’s Macroglobulinaemia
Part VI: Prognostic Factors
19. Risk Stratification in Waldenström Macroglobulinemia
Part VII: Treatment Options and Recommendations
20. Indications for Treatment of Waldenström’s Macroglobulinemia
21. Immunotherapy in Waldenström’s Macroglobulinemia
22. Immunomodulatory Agents and Proteasome Inhibitors in Waldenström’s Macroglobulinemia
23. Signal Inhibitors in Waldenström’s Macroglobulinemia
24. High-Dose Therapy and Haemopoietic Stem Cell Transplantation in Waldenström’s Macroglobulinaemia
25. Long-Term Toxicity of Therapy in Waldenström Macroglobulinemia
26. Treatment Recommendations in Waldenström Macroglobulinemia