This sequel to a family hit based on the popular children's book by E.B. White again mixes live action actors with computer-animated cartoon characters. Michael J. Fox returns as the voice of Stuart Little, a three-inch tall talking mouse adopted by a human family in New York City. When his older "brother", George (Jonathan Lipnicki), starts spending more time with his other friends, playing games that Mrs. Little (Geena Davis) feels are too dangerous for the diminutive Stuart, the lonely fellow goes in search of companionship and finds it when he makes the acquaintance of Margalo (voice of Melanie Griffith), a tiny bird wounded by a sinister falcon (voice of James Woods) that is relentlessly pursuing her. While Margalo's busted wing heals up the Littles' house, Stuart grows closer to her and falls in love, but his new pal is hiding a secret that involves the villainous falcon and jewelry theft. In order to save his friend and their friendship, Stuart must call upon the assistance of the dreaded Snowbell (voice of Nathan Lane), the Little family cat with a Catskills comic delivery and no great love of Stuart.